Take charge of your long-term brain health with daily enzymes to slow brain aging at a cellular level. Found in nature and validated by the National Institutes of Health.

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204 reviews

Take charge of your long-term brain health with daily enzymes to slow brain aging at a cellular level. Found in nature and validated by the National Institutes of Health.


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  • Turn Back The Clock
  • Upgrade Working Memory
  • Help Your Brain Age

Key Features

✔ Take control of your long-term brain health.

✔ Daily enzymes designed to slow atrophy as the brain ages.

✔ Made with ingredients validated by the National Institutes of Health.

What Is It?

NAD stands for Nicotinamide Adenine Dinucleotide. It's a natural molecule found within every living cell of your body. We depend upon NAD to convert the nutrients in our food into cellular capacity and to activate natural self-repair pathways that keep our cells in good working order.

Scientific studies have demonstrated that boosting NAD results in reversal of age-related damage back to a more youthful state. A growing body of scientific research now suggests one of the best ways to combat aging is to maintain high levels of NAD as you age.

How Does it Work?

Grey Matter in the brain, responsible for learning and memory, can decline up to 20% in your adult years, even if you maintain a healthy lifestyle. As we age, our brains shrink in volume, memory fades, and lesions develop. It is not all negative nor passive, as biological aging is not tied absolutely to chronological ageing. It is possible to slow biological aging and even reduce risk of age-related decline.

In order to allow our natural self-repairs systems to restore the efficiency of our cells, we must maintain and raise our NAD levels within the cells. This can be done by the foundational elements of sleep, diet, and exercise. Clockwise is just an addition to that to naturally nudging your system to produce more NAD.

How to take?

Take three tablets every morning, with or without food. Each bottle contains a 30-day supply. Created for long-term use in healthy adults of all ages.


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A little help for aging

50% of your NAD levels decline by Age 40. Thanks to science, aging in the brain and body can be managed.

Be Kind to Your Mind

Introducing Clockwise, natural ingredients established by NIH in 2010 to safely raise your cellular capacity (called NAD). We didn’t invent the “fountain of youth,“ we just bottled a way to naturally nudge your own NAD production by 60%, so you lose less ground over time.

Where is the Science?

Thanks to science, brain aging can be slowed. For 25 years, the scientists at the National Institute of Health and university labs have been validating natural coenzymes improvement on your NAD levels (your body's marker of cellular aging). TruBrain's Dr. Andrew Hill is an expert on gerontology and aging of the brain. Dr. Hill has taught sequence gerontology, and the neuroscience of healthy brain aging at UCLA.

Say Hello to TruBrain

We’re not magicians. We’re not going to turn you into a rocket scientist. Unless you’re already a rocket scientist. We’re not Big Pharma. Our products are custom made to boost mental output. We empower people to do their best thinking.

Based on 204 reviews

Ross Statsk

Verified Buyer

Product works as advertised

I have used this product for more than four weeks. I am 35 years old, compete in tough murder and i ran track in college. As a result, my body was a bit worn out to say the least. At times I felt my short term memory and overall energy groggy at best. I was a hard-core Coffee and caffeine drinker to boot. I thought this was going to be a good fit for me to see if it could do something. I took it roughly 4 weeks to see a noticeable and worthwhile change. It worked tremendously. At around two weeks or so into taking the product, my memory felt sharper in my overall energy began to rise. Only funny part was very colorful and memorable dreams. Don’t know why exactly. At the approximate four week mark, I felt healthier and had lasting energy that went into the evening hours. I didn’t have evening drop off or afternoon lull. To add, now that I am at the 6 week mark, I know I will continue to use this product going forward. This product is as advertised as long as you give it the time to work. I really hope this product represents the start of a new turn in the health industry that helps people of all ages live a better, happier, and healthier lifestyle.

Madeline G

Verified Buyer

This supplement is simply fantastic.

I am a certified nutritionist and nurse practitioner, so I don’t just take anything that I “think” might be good for me. Over the last 10 years I have tried many things to improve my overall health and after doing months of research, I decided to give NAD a try. I looked at several companies but this brand stood out due to their dedication to research, great reviews from trusted sources and always seeming to be on the forefront of science with all of their products. The research on clockwise/TRUbrain speaks for itself but I personally have noticed a considerable difference when taking this in my energy levels, ability to focus and just a sense of overall well being. I’ve used a lot of great products throughout the years and this one is at the very top of the list.

Lizette Margusqa

Verified Buyer

5.0 out of 5 stars

I have taken Trubrain Clockwise for 6 months. My muscle soreness is basically gone and my hair is slowly returning to its original color. I’ll take less gray any day.

Curtis C.

Verified Buyer

This product has made a difference to me in several...

This product has made a difference to me in several ways. First, it has given me a clear mind. I feel very alert. Second, I have more energy than before, and I am 71, almost 72!


Verified Buyer

Less recovery time

I am 68 and this stuff gives me more energy in my workouts and less recovery time when I over do it. Improves my focus and stamina at my job. I am less tired after my 3 mile runs. Read up on the studies and trials-this is the real deal!

Hailee Solvig

Verified Buyer

Big thank you!

I have been taking this routinely in the morning and already within the first week I have noticed some amazing results. My brain function has majorly increased, leaving me with an endurance I haven't felt in years. Along with this, my moods feel vastly more stable! And this is coming from someone with crippling anxiety that comes and goes in waves. As for a tell tale sign for my body, I notice that even before my morning coffee, I already feel ready to tackle the day just a little while after taking this pill in the morning. Amazing. I will continue purchasing and taking this supplement for many years to come. Big thank you!

Warner Stedz

Verified Buyer

Started 4 months ago.

I feel it is helping with my high intensity interval training recovery. No side effects. Will keep taking this in my routine and monitoring results. I admit it can be challenging to isolate what may be helping with your health. However, I add or take away one supplement at a time and I do associate NAD+ with improved recovery over time.

juan c

Verified Buyer

so far, so good

Seems to be a great product . about a week ago i started using this so i should update everyone later on the effectiveness. Product packaging is clean and nice and it arrived early . So far ,I have noticed an increase in energy and I’m looking forward to seeing how these help after using for a month.

Dalia Puldere

Verified Buyer

Pleasantly surprised by this product...

Pleasantly surprised by this product. It took a little over a month to work, but I started noticing a bit more energy recently. I'm also taking other products, one of which is collagen which could also be a factor in the energy boost, along with other natural supplements and exercise and diet. But I'm overall satisfied with the products from trubrain.

Terrence V

Verified Buyer

Expensive, but worth it.

I feel younger and clearer minded than I ever have in my life. I feel like my healthy lifestyle efforts are exponentially enhanced with this. Part of my creative routine along with my magnesium threonate.


Verified Buyer

Cause or Correlation?

I don’t know and I don’t care but I am guessing it is not a coincidence that since I started taking Clockwise I have more energy (working out sometimes twice a day), lost around 15 pounds (must have been all fat), started sleeping better and overall feel healthier. I’ve also stopped drinking alcohol, not sure why but I just don’t. That could be an answer there ha ha. Either way, it all works as a system and i’m loving that system!

Joy Thomas

Verified Buyer


Simple - I love this product and feel the benefits.

Neil Glarsk

Verified Buyer

Part of an approach

Clockwise is part of my plan of attack to have solid energy for as long as I am healthy and active. At 74 I think more about that sort of thing than someone younger. However, I climb a mountain every week so who knows maybe trubrain has something to do with me being able to do that.

Paxton C

Verified Buyer

more like a vitamin

To met his is more like a vitamin-lik effect where I don’t feel any big difference but I just take it anyway b/c it cant hurt.


Verified Buyer

I think of this being a long-term investment...

I think of this as being a long-term investment in my core health. I live in Palm Beach and i’m 58 years old. This has sound science behind it. Sure, the immediate noticeable effects may be subtle (if at all). But that's not what I'm after. What I'm after is a vigorous, healthy, bouncy, and energetic me into my “sunset years” in sunny Florida!

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