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What are ketones?

Ketones are the most efficient energy source that the body produces - good news is that it’s frictionless energy - bad news is that it’s elusive and stubborn to activate within the body in our stressful carb-heavy lifestyle.

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Ketones are lipid-derived, organic compounds that serve as a circulating energy source for tissues. Under normal physiological conditions with ample carbohydrates, Ketone concentrations are relatively low (~0.1-0.5mol/L), but in conditions of limited carbohydrate availability, or with Ketone supplementation with food and beverage, Ketone levels are increased and available from fatty acids converting into Ketones. The thermal energy, meaning the body’s energy from heat for metabolization, required to make use of Ketones is less than that of fats or carbs, contributing to the reason they are a compelling source of energy for athletes for endurance athletics, cognitive energy supplies from brain metabolism, and even in resting state.

How Do Ketones Work?

Ketones allow your body to return to its most natural state of digestion. Normally, the body relies on carbohydrates or sugar (whatever you have recently consumed) for energy. These are quick-burning and require a constant need causing cyclic energy swings. However, once these resources are used, the body adapts to creating energy from protein and fat (ketogenic state). Ketones provide a constant energy without the need for sacrificing a normal diet.

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Ketones are lipid-derived, organic compounds that serve as a circulating energy source for tissues. Under normal physiological conditions with ample carbohydrates, Ketone concentrations are relatively low (~0.1-0.5mol/L), but in conditions of limited carbohydrate availability, or with Ketone supplementation with food and beverage, Ketone levels are increased and available from fatty acids converting into Ketones.

How Do We Know It Works Scientifically?

With new technological breakthroughs, you are now able to test Ketone levels easily through blood and breath analysis. Without Ketones and/or a Keto diet, the body’s normal ketone level rests below 0.6 mmol/L. TruBrain Ketones will stoke your natural production to a level between 1-1.5 mmol/L within an hour and persist at this level for about 4 hours.

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Are Ketones Safe?

The body normally maintains a ketone level of 0-0.6 mmol/L without any dietary adjustment. TruBrain Ketones will nudge your natural production to a level of 1-1.5 mmol/L. This level causes no side effects and is natural for the human body’s digestion.

Why would I take Ketones instead of strict fasting and high fat diet?

While you can achieve high Ketone levels (3, 4 or 5 on our scale below) by adhering to a strict, disciplined routine of fasting, athletics, and diet changes, our Ketones are a safe, easy, and natural way to nudge your own production of Ketones to complement this process.

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The consensus from the scientific community is that Ketone drinks like ours offer a practical alternative to increase Ketone concentrations without as much rigorous adherence to a high fat, low carb, and fasting routine on an ongoing basis. For folks seeking level 5, our drinks help sustain and support these efforts and we applaud you {clap emoji}

Ketone Expert Backed

Our Head of Growth, Alyssa Warth, has worked on multiple published ketone studies such as "Recovery of Outcome Measures Following Traumatic Brain Injury is Dependent on Fuel Type and Timing" "Ketogenic Diet Decreases Oxidative Stress and Improves Mitochondrial Respiratory Complex Activity" and "Food for Thought: Alternative Fuel Supplementation is Dependent on Metabolic State." She specializes in Ketone usage for athletic performance and recovery.

Scientific Citations

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Sato, K., Kashiw.aya, Y., Keon, C.A., Tsuchiya, N., King, M.T., Radda, G.K., Chance, B., Clarke, K., and Veech, RL. (1995). Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J. 9, 651-658.

Cox, P.J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, Andrew J., Stubbs, B., West, J., McLure, Stewart W., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 24, 1-13.

Stubbs, B.Cox, P.; Evans, R.; Santer, P.; Miller, J.; Faull, O.; Magor-Elliott, S.; Hiyama, S.; Stirling, M.; Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Front. Physiol.

Cahill, G.F., Jr. (1970). Starvation in man. New Engl J Med 282, 668-675.

Murray, A.J., Knight, N.S., Cole, M.A., Cochlin, L.E., Carter, E., Tchabanenko, K., Pichulik, T., Gulston, M.K., Atherton, H.J., Schroeder, M.A., et al. (2016). Novel ketone diet enhances physical and cognitive performance. FASEB J.

Veech RL, Bradshaw PC, Clarke K, Curtis W, Pawlosky R, King MT. Ketone bodies mimic the life span extending properties of caloric restriction. IUBMB Life. 2017;69(5):305-314.